Uniform Drug Loading into Prefabricated Microparticles by Freeze‐Drying

Microparticle‐based drug delivery is a promising technology for small volume bioassay platforms. The general utilization of the drug‐loaded microparticles in the in vitro bioassay platforms requires the drug loading method, which should impregnate the general drug types (e.g., water insoluble) with high payload into the variously designed microparticles. Loading the drug into the prefabricated microparticles using solvent evaporation satisfies the requirement. However, similar to the “coffee‐ring effect,” drugs are loaded in a seriously nonuniform manner, caused by the capillary flow during the evaporation process. Here, it is presented that the freeze‐drying is an efficient way to load uniform and high amount of the drug into the prefabricated microparticles. It is demonstrated that freezing solvent can block the capillary flow during the solvent removal process, improving the loading uniformity. The delivered amount of drugs is linearly proportional to the initial loading amount of drugs. Also, this drug loading method is shown to be applied to the various drug types and the prefabricated microparticles with different properties. Considering many challenges to suppress the “coffee‐ring effect” that induces nonuniform impregnation/deposition, the proposed concept can be applied not only for microparticle‐based drug delivery but also for uniform coating applications (e.g., thin‐film coating, DNA/protein microarray).     

On the Uniform Convergence of Walsh-Fourier Series

We study the uniform convergence of Walsh-Fourier series of functions on the generalized Wiener class BV (p(n)↑∞) This revised version was published online in June 2006 with corrections to the Cover Date.     

On the Uniform Convergence of the Empirical Density of an Ergodic Diffusion

We investigate the uniform convergence of the density of the empirical measure of an ergodic diffusion. It is known that under certain conditions on the drift and diffusion coefficients of the diffusion, the empirical density f _t converges in probability to the invariant density f, uniformly on the entire real line. We show that under the same conditions, uniform convergence of f _t to f on compact intervals takes place almost surely. Moreover, we prove that under much milder conditions (the usual linear growth condition on the drift and diffusion coefficients and a finite second moment of the invariant measure suffice), we have the uniform convergence of f _t to f on compacta in probability. This revised version was published online in June 2006 with corrections to the Cover Date.     

A note on 3‐factorizations of K10*

In this note, we enumerate all nonisomorphic 3‐factorizations of K₁₀. © 2001 John Wiley & Sons, Inc. J Combin Designs 9: 379–383, 2001     

Finite volume multigrid method of the planar contraction flow of a viscoelastic fluid

This paper reports on a numerical algorithm for the steady flow of viscoelastic fluid. The conservative and constitutive equations are solved using the finite volume method (FVM) with a hybrid scheme for the velocities and first‐order upwind approximation for the viscoelastic stress. A non‐uniform staggered grid system is used. The iterative SIMPLE algorithm is employed to relax the coupled momentum and continuity equations. The non‐linear algebraic equations over the flow domain are solved iteratively by the symmetrical coupled Gauss–Seidel (SCGS) method. In both, the full approximation storage (FAS) multigrid algorithm is used. An Oldroyd‐B fluid model was selected for the calculation. Results are reported for planar 4:1 abrupt contraction at various Weissenberg numbers. The solutions are found to be stable and smooth. The solutions show that at high Weissenberg number the domain must be long enough. The convergence of the method has been verified with grid refinement. All the calculations have been performed on a PC equipped with a Pentium III processor at 550 MHz. Copyright © 2001 John Wiley & Sons, Ltd.     

均匀设计抽样的一、二阶矩

（７）中给出并研究了均匀设计抽样（ＵＤＳ）及随机化均匀设计（ＲＵＤ）的一些优良性质，作者给出该设计和抽样的一、二阶矩。     

Randomization time for the overhand shuffle

This paper analyzes repeated shuffling of a deck ofN cards. The measure studied is a model for the popularoverhand shuffle introduced by Aldous and Diaconis. It is shown that convergence to the uniform distribution requires at least orderN ² shuffles, and that orderN ² log(N) shuffles suffice. For a 52-card deck, more than 1000 shuffles are needed.     

Spin precession of a charged particle in a uniform magnetic field on a static space-time

We investigate the ratio of spin precession frequency to orbital frequency for a spinning charged particle confined to circular orbit in the equatorial plane of a compact object, with a uniform magnetic field, as described by the Wald and the Ernst potentials. In order to see the difference in behaviours for particles with differentg values we consider the cases of electron and proton separately.     

Infeasible-interior-point algorithm for a class of nonmonotone complementarity problems and its computational complexity

This paper presents an infeasible-interior-point algorithm for a class of nonmonotone complementarity problems, and analyses its convergence and computational complexity. The results indicate that the proposed algorithm is a polynomial-time one.